This episode has a fun personal twist: There’s a counterfactual world where I was employee #1 at Genesis Molecular AI , the company behind today’s episode. A certain introduction happened a few weeks too late and I had already happily signed at Atomwise, another ML-for-drug-discovery startup. Same problem, different company. I was certain ML was going to transform small molecule drug discovery. Early results were underwhelming. Useful at times, but nowhere near revolutionary. In the last year I’
Anthony Kaldellis is a historian of the Roman Empire and author of “The New Roman Empire”, a comprehensive history of the Byzantine Empire (Eastern Roman Empire). Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep498-sc See below for timestamps, transcript, and to give feedback, submit questions, contact Lex, etc. Transcript: https://lexfridman.com/anthony-kaldellis-transcript CONTACT LEX: Feedback – give feedback to Lex: https://lexfridman.com
Anthony Kaldellis is a historian of the Roman Empire and author of "The New Roman Empire", a comprehensive history of the Byzantine Empire (Eastern Roman Empire). Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep498-sb See below for timestamps, transcript, and to give feedback, submit questions, contact Lex, etc. Transcript: https://lexfridman.com/anthony-kaldellis-transcript CONTACT LEX: Feedback - give feedback to Lex: https://lexfridman.com/survey *AMA
We’re excited to have Databricks join us at AIEWF , among hundreds of the top companies in the AI Engineer ecosystem. LS subscribers can use their discount to get past the late bird pricing and access over $50k in sponsor offers ! Everyone is still talking about Satya’s Frontier Ecosystems post , but few have actually built a ( now $175 billion ) frontier ecosystem and cloud like our guests today. From open-sourcing the layer above coding agents to rethinking databases for the agent era, Databri
AI Engineer World’s Fair regular bird tix will sell out ~today! Join us next week ahead of the Late Bird price hike and get >$40,000 in sponsor credits for attending ! Thanks to the US Government issuing an export control directive on Mythos and Fable , the risks of jailbreaks and (industry term) indirect prompt injection are suddenly the talk of the town, though we have been covering AI security for a few years now, from Hackaprompt to the enigmatic Pliny the Elder . Zico Kolter, member of Open
Last 4 days before regular tickets sell out at AI Engineer World’s Fair - this is the single biggest gathering of AI Engineers, Founders, Leaders, and Researchers in the world. Attendees get >$5000 worth of sponsor credits and talk tracks are looking FANTASTIC. Join us! The AI scaling debate always focuses on the question of “how do we get more GPUs?” but the better question may be: how do we make the most of ones we already have. The fact that a frontier lab like xAI could be running at sub-10%
On the Science pod, we’ve been covering a lot of the ground on how AI is revolutionizing STEM, but one of our favorite off the record topics since our launch is which field is harder to accelerate: math , bio , or physics ? Today we’re back in Materials Science land with Radical — Unlike biological molecules that can be represented (and predicted!) by token strings, the success of materials involve many more macro complex variables like supply chains, microstructures, and manufacturing processes
The new AIEWF website is live! Get your tickets booked ASAP as they -will- sell out. Take the AI Engineering Survey and get >$2k in credits and free AIE WF tickets ! Most industry benchmarks compress intelligence and reasoning ability into scores. SWE-Bench Pro , MMLU , Humanity’s Last Exam , etc. These metrics are useful, but don’t always represent the full extent of how a model performs in the real world . Some of the most interesting evals today look less like exams and more like operating bu
In 2025, seven-month-old startup Axiom solved all 12 of the problems Putnam exam (scoring 8/12 in the time limit) a prestigious undergraduate math exam. The 12/12 score is better than the top undergraduates (110/120) and the closest AI system that reported a result (DeepSeek 103/120), although it is unclear what the people and other systems would have scored with more time. Nonetheless, the Putnam exam is legendary for its difficulty, with the median score typically being 0 or 1 points. Taken by
Don Lincoln is a particle physicist at Fermilab who has spent decades working at the frontiers of high energy physics. Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep497-sc See below for timestamps, and to give feedback, submit questions, contact Lex, etc. CONTACT LEX: Feedback – give feedback to Lex: https://lexfridman.com/survey AMA – submit questions, videos or call-in: https://lexfridman.com/ama Hiring – join our team: https://lexfridman
Don Lincoln is a particle physicist at Fermilab who has spent decades working at the frontiers of high energy physics. Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep497-sb See below for timestamps, transcript, and to give feedback, submit questions, contact Lex, etc. Transcript: https://lexfridman.com/don-lincoln-transcript CONTACT LEX: Feedback - give feedback to Lex: https://lexfridman.com/survey AMA - submit questions, videos or call-in: https://l
Jean-Baptiste Kempf is lead developer of VLC and president of VideoLAN. Kieran Kunhya is a longtime FFmpeg contributor, codec engineer, and the person behind the now-infamous FFmpeg account on X. Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep496-sc See below for timestamps, transcript, and to give feedback, submit questions, contact Lex, etc. Transcript: https://lexfridman.com/ffmpeg-transcript CONTACT LEX: Feedback – give feedback to Lex: https://lexf
Jean-Baptiste Kempf is lead developer of VLC and president of VideoLAN. Kieran Kunhya is a longtime FFmpeg contributor, codec engineer, and the person behind the now-infamous FFmpeg account on X. Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep496-sb See below for timestamps, transcript, and to give feedback, submit questions, contact Lex, etc. Transcript: https://lexfridman.com/ffmpeg-transcript CONTACT LEX: Feedback - give feedback to Lex: https://lexf
Lars Brownworth is a historian, teacher, podcaster, and author specializing in Viking history, medieval Europe, and the Byzantine Empire. Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep495-sc See below for timestamps, transcript, and to give feedback, submit questions, contact Lex, etc. Transcript: https://lexfridman.com/lars-brownworth-transcript CONTACT LEX: Feedback – give feedback to Lex: https://lexfridman.com/survey AMA – submit questions, v
Lars Brownworth is a historian, teacher, podcaster, and author specializing in Viking history, medieval Europe, and the Byzantine Empire. Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep495-sb See below for timestamps, transcript, and to give feedback, submit questions, contact Lex, etc. Transcript: https://lexfridman.com/lars-brownworth-transcript CONTACT LEX: Feedback - give feedback to Lex: https://lexfridman.com/survey AMA - submit questions, video
Jensen Huang is the co-founder and CEO of NVIDIA, the world’s most valuable company and the engine powering the AI computing revolution. Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep494-sc See below for timestamps, transcript, and to give feedback, submit questions, contact Lex, etc. Transcript: https://lexfridman.com/jensen-huang-transcript CONTACT LEX: Feedback – give feedback to Lex: https://lexfridman.com/survey AMA – submit questions,
Jensen Huang is the co-founder and CEO of NVIDIA, the world's most valuable company and the engine powering the AI computing revolution. Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep494-sb See below for timestamps, transcript, and to give feedback, submit questions, contact Lex, etc. Transcript: https://lexfridman.com/jensen-huang-transcript CONTACT LEX: Feedback - give feedback to Lex: https://lexfridman.com/survey AMA - submit questions, videos or
Jeff Kaplan is a legendary Blizzard game designer of World of Warcraft and Overwatch, now preparing to launch a new game, The Legend of California, from his new studio Kintsugiyama – available to wishlist on Steam today, with alpha later in March. Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep493-sc See below for timestamps, and to give feedback, submit questions, contact Lex, etc. CONTACT LEX: Feedback – give feedback to Lex: https://lexfridman.
Jeff Kaplan is a legendary Blizzard lead game designer of World of Warcraft and Overwatch, now preparing to launch a new game, The Legend of California, from his new studio Kintsugiyama - available to wishlist on Steam today, with alpha later in March. Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep493-sb See below for timestamps, transcript, and to give feedback, submit questions, contact Lex, etc. Transcript: https://lexfridman.com/jeff-kaplan-transcript
Training with Khabib Nurmagomedov, one of the greatest fighters of all time and a great human being. This was truly an honor for me 🙏 Full video is on YouTube.