BitMine is within reach of owning 5% of ETH after more than 60 consecutive weeks of purchases, and Tom Lee believes the larger Ethereum trade may only be beginning. He joins David to explain how BitMine accumulated nearly 5% without debt, why it sometimes chooses stock buybacks over additional ETH, what happens when the target is reached, and whether the company would ever sell. --- 📣SPOTIFY PREMIUM RSS FEED | USE CODE: SPOTIFY24 https://bankless.cc/spotify-premium --- BANKLESS SPONSOR TOOLS: �
Julien Bek is a Partner at Sequoia Capital, one of the most renowned venture firms in the world. At Sequoia, he has partnered with companies including Rillet, Tacto, and Auctor. Before joining Sequoia, Julien spent five years at Accel, where he worked with companies including Miro, Melio, and BeReal. He is also an angel investor in Revolut and Attio. AGENDA: 06:35 – What did Julien only discover about Sequoia after joining the firm? 08:05 – What does everyone get wrong about Sequoia? 13:00 – Is
Jerry Murdock is the Co-Founder of Insight Partners, which manages over $90 billion in assets. Jerry personally backed companies including Twitter, Nest and Docker, while Insight's portfolio includes giants such as Shopify, Wiz and monday.com. Across three decades, Insight has helped produce 55+ IPOs and become one of the most powerful technology investment firms in the world. AGENDA: 00:00 — Is the AI Bubble About to Burst? 11:00 — Will Half of All Neoclouds Disappear Within 36 Months? 13:00 —
Niels Kaastrup-Larsen and Mark Rzepczynski examine the warning signs emerging beneath seemingly calm markets, from extreme single-stock moves and commodity shortages to growing strains in the U.S. Treasury market. They explore how leveraged hedge funds and basis trades have become increasingly important to Treasury liquidity, and why market plumbing can matter as much as price signals. The conversation then turns to the evolution of trend following, comparing different approaches to signals and
When we first dicsussed the Summer of Simulative AI in 2024 we knew it would be a brief summer, but it has recently come back with a vengeance with SimGym in April and now Simile AI’s $2B Series B , backed by GreenOaks and Index Ventures with prominent backers like Fei-Fei Li and Andrej Karpathy, running tens of millions of simulations for Fortune 100 clients like CVS and 85–99% accuracy vs human focus groups. Time to catch up on why this Second Summer of simulation is working! From creating Sma
Crypto just had one of its biggest breakout days in years. Ryan and David unpack the Treasury’s QE-like move, the White House and SEC’s crypto push, ETH’s violent rebound, and whether this rally finally broke the back of the bear market. --- 📣SPOTIFY PREMIUM RSS FEED | USE CODE: SPOTIFY24 https://bankless.cc/spotify-premium --- BANKLESS SPONSOR TOOLS: 🔓 NEAR | TRADE CONFIDENTIALLY, GET 20% BACK https://bankless.cc/near-pod 🔑 BITKEY | GET 10% OFF USE CODE: BANKLESS | #bitkeypartner https://ban
Ethereum may be paying too much to secure itself, and the consequences could extend far beyond a little extra ETH issuance. Jerome de Tychey, co-author of EIP-8363, and Sam Jernigan join David Hoffman to make the case for stake targeting, a proposal designed to stop Ethereum’s staking ratio from climbing indefinitely. They debate what happens if more than half of ETH becomes staked, whether today’s issuance threatens credible neutrality, why staking may be crowding out DeFi, what lower rewards c
AGENDA: 04:20 Elon's Deal of the Decade: SpaceX Buys Cursor for $60BN 06:10 Why Cursor Was Surprisingly Cheap at $60BN 07:00 Why Zuckerberg Failed to Buy the AI Prize Elon Secured 12:00 Elon vs Zuck: Who Would You Rather Work For? 14:00 Will Microsoft or Amazon Now Race to Buy Cognition? 17:05 Stripe's $7BN OpenRouter Deal Creates Huge VC Winners 25:00 OpenRouter's Fatal Risk: Enterprises Don't Want 10 Models 28:15 Anthropic Turns Its First Profit on $11.5BN of Quarterly Revenue 32:15 Can Anthro
Alan Dunne is joined by Mike Pyle, Deputy Head of BlackRock’s Portfolio Management Group, to explore how a supply-driven world is reshaping markets and portfolio construction. They discuss the transition from the demand-constrained 2010s to an era defined by scarcity, fiscal activism, geopolitical shocks and the immense capital demands of AI. Pyle explains why bonds may no longer provide the diversification they once did, why hedge funds and market-neutral strategies are becoming increasingly im
Andrew Macdonald (Mac) is the longest-serving employee at Uber. Today, he is the President and COO. No one on the planet has spent more time mastering ride-sharing than Mac. Uber now does 300M rides per week, has 200M users, and is one of the most recognised brands on the planet. Mac never does interviews and so this was a rare look behind the scenes at the Uber machine. AGENDA: 05:39 – How was Mac the only survivor from the Travis era? 10:39 – How does Uber decide what to include in Uber One me
The Fed may no longer be a one-person institution, and markets are not ready for the consequences. Jim Bianco joins David Hoffman to unpack Kevin Warsh's emerging 12-voter Fed, the end of forward guidance, and the counterintuitive case that higher short-term rates could actually pull long-term yields lower. They also explore sticky inflation, why balance sheet reduction cannot happen overnight, how AI capex is reshaping the economy, why the AI bubble may look more like 1998 than 2000, and why Bi
Matt Swulinski is one of the best growth leaders in AI. He is currently Head of Growth at Viktor, the Accel-backed AI coworker. Previously, he was Head of Growth at Wispr Flow, where he was marketing hire #1 and built the growth function from pre-launch to millions of users. Matt also built the AI-powered marketing OS that automated 100 newsletter sponsorships a month and enabled a lean team to scale dramatically faster. Before Wispr Flow, Matt worked in growth at Superhuman. AGENDA: 00:00 Why S
Niels Kaastrup-Larsen is joined by Andrew Beer and Tom Wrobel to examine a remarkable period for systematic investing. They discuss how CTAs have navigated volatile moves across equities, commodities, currencies and rates while preserving strong gains, and why diversification has been central to that resilience. The conversation explores leverage, the renewed interest in managed accounts and portable alpha, alongside the growing distinction between trend and non-trend strategies. They also chall
EtherFi is expanding from a crypto-native neobank into a broader financial account built around DeFi. Mike Silagadze joins David to break down the next version of the product, including tokenized stocks and metals, Aave V4-powered credit, yield-bearing balances, global fiat rails, and a much more normie-friendly experience. --- 📣SPOTIFY PREMIUM RSS FEED | USE CODE: SPOTIFY24 https://bankless.cc/spotify-premium --- BANKLESS SPONSOR TOOLS: 🔓NEAR | TRADE CONFIDENTIALLY, GET 20% BACK https://bankl
Bitcoin’s latest fork died after just two blocks. Ryan and David unpack what the failure says about Bitcoin maximalism, why Saylor keeps selling BTC, Robinhood Chain’s breakout, and Fidelity’s push to bring staking yield to Wall Street. --- 📣SPOTIFY PREMIUM RSS FEED | USE CODE: SPOTIFY24 https://bankless.cc/spotify-premium --- BANKLESS SPONSOR TOOLS: 🔓NEAR | TRADE CONFIDENTIALLY, GET 20% BACK https://bankless.cc/near-pod 🔑BITKEY | GET 10% OFF USE CODE: BANKLESS | #bitkeypartner https://bankle
AGENDA: 05:00 Canva's Growth Gets Slashed as AI Costs Explode 20:00 The Great Software Reset: Why 2026 Will Punish AI Hesitancy 29:00 Canva's Valuation Reality Check—and the LP Liquidity Trap 35:00 Google's AI Brain Drain: Jeff Dean Leaves, Demis Steps Back 43:00 Why Google Can't Afford to Cure Alzheimer's 50:00 The Data-Centre Revolt: Can AI Survive the Political Backlash? 55:00 Elon Musk's $55BN Terrafab Bet to Break Free from TSMC 57:00 Revolut's $50BN CEO Pay Package—and the Return of Founde
Khabib Nurmagomedov is one of the greatest fighters of all time, who retired from the UFC undefeated with a perfect 29-0 record. We did this conversation entirely in Russian. It’s translated and dubbed into English. Both language audio tracks (and subtitles) are available on YouTube. Here, only the English audio is available. We worked hard to make it enjoyable to listen to, by carefully dubbing the translation using voice-cloning, as we’ve done for previous foreign-language podcasts
Khabib Nurmagomedov is one of the greatest fighters of all time, who retired from the UFC undefeated with a perfect 29-0 record. We did this conversation entirely in Russian. It's translated and dubbed into English. Both language audio tracks (and subtitles) are available here on YouTube. To switch between language audio tracks, click: Settings gear icon, then Audio track. Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep500-sb See below for timestamps, transcr
Charles-Henry Monchau joins Alan Dunne to discuss how geopolitics, artificial intelligence and structural economic shifts are reshaping global investing. They explore the AI supercycle, the changing balance between the US, China and Europe, sovereign debt, inflation, commodities and the future of asset allocation. Charles explains why investors should focus on long-term structural themes rather than short-term market noise and why the biggest opportunities may lie beyond the current AI infrastru
This January, four big AI × Pharma tools deals were announced at the huge JPM Pharma conference that takes over San Francisco every year. OpenAI-backed Chai Discovery ( now worth $4B ) was somehow at the heart despite being all of 2 years old. The Science team is proud to bring you the first podcast with cofounder Matt McPartlon and product lead Neil Patil to tell the full story! Editor’s note: not to be confused with Chai AI , which was another top pod of ours. Pharma suddenly doing big AI tool